49ers Starting Lineup 2026
The 49ers start Brock Purdy at quarterback, Christian McCaffrey at running back and George Kittle at tight end. Mike Evans, Deebo Samuel and Brandin Cooks start at receiver. Week 5, from the depth chart the team filed (as of 2026-10-06) and the injury report (as of 2026-10-08). 1 starter is out this week, so the next man up is listed in his spot.
49ers offense
| Pos | Starter | Next up |
|---|---|---|
| QB | Mac Jones | |
| RB | Kaelon Black | |
| WR |  Mike Evans | |
| WR | DSDeebo Samuel | |
| WR |  Brandin Cooks | Jacob Cowing |
| TE | Luke Farrell | |
| LT | Vederian Lowe | |
| LG | Carver Willis | |
| C | Jarrett Patterson | |
| RG | ||
| RT |
49ers defense
| Pos | Starter | Next up |
|---|---|---|
| LDE | Romello Height | |
| LDT | Naquan Jones | |
| RDT | James Thompson Jr. | |
| RDE | Ogbo Okoronkwo | |
| SLB | Luke Gifford | |
| MLB | Tatum Bethune | |
| WLB | Garret Wallow | |
| LCB | Jack Jones | |
| RCB | Ephesians Prysock | |
| FS | Siran Neal | |
| SS |  Malik Mustaphain for Marques SigleOUT | Ashtyn Davis |
Special teams
| Pos | Starter | Next up |
|---|---|---|
| K | ||
| P | ||
| LS | ||
| KR | DSDeebo Samuel | Jacob Cowing |
| PR | Jordan Watkins |
Base personnel: three receivers and one tight end on offense; on defense, the base front plus the slot corner when the base set is short of 11. Rebuilt every Tuesday with the depth chart.
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Source: the depth chart each team files with the league, via nflverse, and the official injury report. Player links go to the StickToTheModel profile.