49ers Depth Chart 2026
Week 6 chart, as of 2026-10-15, from the team's official submission. Starters first, then the backups in order. Rebuilt every Tuesday. Just the 22 who take the field: 49ers starting lineup.
| Pos | Starter | Second | Third | Others |
|---|---|---|---|---|
| Offense | ||||
| QB | Mac Jones | Kurtis RourkeOUT | ||
| RB | Kaelon Black | Jordan James | Isaac Guerendo | |
| FB | — | — | ||
| WR |  Mike Evans | Deebo Samuel | Brandin Cooks | Jacob Cowing, Jordan Watkins, Christian KirkIR, Demarcus RobinsonIR, De'Zhaun StriblingIR, Ricky Pearsall, Brandon AiyukOUT |
| TE | Luke Farrell | Brayden Willis | Jake TongesIR | |
| LT | Vederian Lowe | Enrique Cruz Jr.OUT | Austen Pleasants | |
| LG | Carver Willis | Nick Zakelj | ||
| C | Jarrett Patterson | Brett Toth | ||
| RG | — | — | ||
| RT | — | — | ||
| Defense | ||||
| LDE | Romello Height | Khalid Kareem | Sam Okuayinonu, Mikail Kamara | |
| LDT | Naquan Jones | Sebastian Valdez | C.J. WestIR | |
| RDT | James Thompson Jr. | Alfred CollinsIR | ||
| RDE | Mykel Williams | Andrew Farmer II | ||
| SLB | Luke Gifford | — | ||
| MLB | Tatum BethuneOUT | Nick MartinIR | ||
| WLB | Garret WallowOUT | — | ||
| LCB | Jack Jones | — | ||
| RCB | Ephesians Prysock | Nate Hobbs | ||
| NB | — | — | ||
| FS | Siran Neal | Darrick Forrest | ||
| SS | Malik Mustapha | Ashtyn Davis | ||
| Special Teams | ||||
| K | — | — | ||
| P | — | — | ||
| LS | — | — | ||
| H | — | — | ||
| KR | DSDeebo Samuel | Jacob Cowing | Isaac Guerendo | |
| PR | Jordan Watkins | Ricky Pearsall | ||
In the base three-receiver set the first three receivers all start. OUT and IR tags come from the injury report as of 2026-10-15.
What changed since Week 5
No new starters: the 49ers listed the same first-string players at every spot as last week.
49ers offense
Brock Purdy starts at quarterback for the 49ers, with Mac Jones behind him. Christian McCaffrey is the lead back; Kaelon Black is next. The three receivers listed first are Mike Evans, Deebo Samuel and Brandin Cooks. George Kittle is the starting tight end. The offensive line, left tackle to right tackle: Trent Williams, Connor Colby, Jake Brendel, Dominick Puni, Colton McKivitz.
49ers defense
The 49ers defensive front starts Keion White, Osa Odighizuwa, Gracen Halton and Nick Bosa. The linebackers listed first are Jaden Dugger, Fred Warner and Dre Greenlaw. Renardo Green and Deommodore Lenoir are the starting cornerbacks, with Upton Stout in the slot. Ji'Ayir Brown and Marques Sigle start at safety.
Out or on injured reserve as of 2026-10-15: Alfred Collins (IR, knee, eligible back 2027-02-15); C.J. West (IR, eligible back 2026-10-25); Christian Kirk (IR, calf, eligible back 2026-10-25); De'Zhaun Stribling (IR, ankle, eligible back 2026-11-22); Demarcus Robinson (IR, ankle, eligible back 2026-10-25); Jake Tonges (IR, knee - mcl, eligible back 2027-02-15); Nick Martin (IR, hamstring, eligible back 2026-10-19); Brandon Aiyuk (OUT, personal); Deebo Samuel Sr. (OUT, hamstring); Enrique Cruz Jr. (OUT, coach's decision); Garret Wallow (OUT, hamstring); Kurtis Rourke (OUT, coach's decision); Tatum Bethune (OUT, coach's decision).
Who is the 49ers starting quarterback?
Brock Purdy is the 49ers starting quarterback on the Week 6 depth chart.
Who is the 49ers backup quarterback?
Mac Jones is the backup, listed second behind Brock Purdy, with Kurtis Rourke third.
Who are the 49ers starting running back and receivers?
Christian McCaffrey is the lead running back; Mike Evans, Deebo Samuel and Brandin Cooks are the top receivers; George Kittle starts at tight end.
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Source: the depth chart each team files with the league, via nflverse, refreshed on Tuesdays. Player links go to the StickToTheModel profile. For the interactive version, with the roster and cap underneath it, open Team HQ.