| # | Player | PPR Pts | Stat Line | Season Pts | Season Rank |
|---|---|---|---|---|---|
| 1 | Chase Brown RB CIN | 32.9 | 12 car, 66 yds, 1 TD; 4 rec, 43 yds, 2 rec TD | 230.8 | RB11 |
| 2 | Christian McCaffrey RB SF | 32.6 | 21 car, 117 yds, 0 TD; 6 rec, 29 yds, 2 rec TD | 374.8 | RB1 |
| 3 | Ashton Jeanty RB LV | 31.8 | 24 car, 128 yds, 1 TD; 1 rec, 60 yds, 1 rec TD | 225.4 | RB14 |
| 4 | Bijan Robinson RB ATL | 29.8 | 16 car, 76 yds, 0 TD; 7 rec, 92 yds, 1 rec TD | 327.6 | RB4 |
| 5 | Jaylen Warren RB PIT | 29.1 | 14 car, 143 yds, 2 TD; 2 rec, 8 yds | 195.8 | RB17 |
| 6 | James Cook RB BUF | 26.4 | 16 car, 117 yds, 2 TD; 1 rec, 17 yds | 298.0 | RB6 |
| 7 | KW Kenneth Walker III RB SEA | 25.4 | 11 car, 100 yds, 1 TD; 3 rec, 64 yds | 166.9 | RB24 |
| 8 | Derrick Henry RB BAL | 24.8 | 18 car, 128 yds, 2 TD | 227.3 | RB12 |
| 9 | Kenneth Gainwell RB PIT | 23.8 | 9 car, 50 yds, 0 TD; 5 rec, 78 yds, 1 rec TD | 195.1 | RB18 |
| 10 | Jahmyr Gibbs RB DET | 22.8 | 7 car, 2 yds, 0 TD; 10 rec, 66 yds, 1 rec TD | 339.9 | RB2 |
| 11 | RJ Harvey RB DEN | 22.1 | 7 car, 50 yds, 1 TD; 4 rec, 71 yds | 185.7 | RB20 |
| 12 | Tyjae Spears RB TEN | 21.5 | 13 car, 52 yds, 1 TD; 5 rec, 53 yds | 100.9 | RB45 |
| 13 | Saquon Barkley RB PHI | 19.2 | 22 car, 132 yds, 1 TD | 225.5 | RB13 |
| 14 | DA De'Von Achane RB MIA | 18.0 | 15 car, 81 yds, 1 TD; 3 rec, 9 yds | 307.9 | RB5 |
| 15 | Jonathan Taylor RB IND | 16.9 | 16 car, 46 yds, 1 TD; 3 rec, 33 yds | 339.0 | RB3 |
| 16 | Travis Etienne RB JAX | 16.6 | 16 car, 50 yds, 0 TD; 4 rec, 16 yds, 1 rec TD | 237.9 | RB9 |
| 17 | Omarion Hampton RB LAC | 16.5 | 16 car, 85 yds, 1 TD; 1 rec, 10 yds | 115.7 | RB41 |
| 18 | Rhamondre Stevenson RB NE | 15.8 | 8 car, 51 yds, 1 TD; 2 rec, 27 yds | 118.3 | RB37 |
| 19 | Zach Charbonnet RB SEA | 15.4 | 10 car, 32 yds, 1 TD; 4 rec, 22 yds | 134.5 | RB27 |
| 20 | CR Chris Rodriguez Jr. RB WAS | 13.9 | 15 car, 63 yds, 1 TD; 1 rec, 6 yds | 76.7 | RB55 |
| 21 | Isiah Pacheco RB KC | 13.5 | 8 car, 34 yds, 0 TD; 6 rec, 41 yds | 84.1 | RB50 |
| 22 | Blake Corum RB LA | 13.1 | 14 car, 48 yds, 1 TD; 1 rec, 13 yds | 112.5 | RB42 |
| 23 | Jaylen Wright RB MIA | 12.3 | 9 car, 35 yds, 1 TD; 1 rec, 18 yds | 38.6 | RB69 |
| 24 | Kyle Monangai RB CHI | 12.3 | 9 car, 50 yds, 0 TD; 3 rec, 43 yds | 131.1 | RB29 |
| 25 | Samaje Perine RB CIN | 12.1 | 7 car, 25 yds, 1 TD; 2 rec, 16 yds | 65.4 | RB59 |
| 26 | Jawhar Jordan RB HOU | 12.0 | 15 car, 53 yds, 0 TD; 5 rec, 17 yds | 25.8 | RB82 |
| 27 | Kyren Williams RB LA | 11.5 | 23 car, 70 yds, 0 TD; 3 rec, 15 yds | 240.2 | RB7 |
| 28 | Aaron Jones RB MIN | 11.3 | 21 car, 85 yds, 0 TD; 2 rec, 8 yds | 105.4 | RB43 |
| 29 | TP Tony Pollard RB TEN | 10.2 | 21 car, 102 yds, 0 TD | 170.8 | RB22 |
| 30 | Quinshon Judkins RB CLE | 10.1 | 8 car, 22 yds, 0 TD; 5 rec, 29 yds | 167.8 | RB23 |
| 31 | Isaiah Davis RB NYJ | 10.0 | 3 car, 8 yds, 0 TD; 4 rec, 52 yds | 66.2 | RB58 |
| 32 | TT Tyrone Tracy Jr. RB NYG | 9.8 | 16 car, 71 yds, 0 TD; 2 rec, 7 yds | 126.2 | RB32 |
| 33 | Tank Bigsby RB PHI | 9.7 | 4 car, 37 yds, 1 TD | 34.3 | RB72 |
| 34 | Trayveon Williams RB CLE | 9.5 | 3 car, 17 yds, 0 TD; 4 rec, 38 yds | 13.1 | RB99 |
| 35 | DS D'Andre Swift RB CHI | 9.0 | 13 car, 58 yds, 0 TD; 2 rec, 12 yds | 204.9 | RB15 |
| 36 | Jacory Croskey-Merritt RB WAS | 8.5 | 8 car, 25 yds, 1 TD | 118.9 | RB36 |
| 37 | Rico Dowdle RB CAR | 8.3 | 9 car, 29 yds, 0 TD; 4 rec, 14 yds | 204.0 | RB16 |
| 38 | Tyler Allgeier RB ATL | 8.3 | 16 car, 79 yds, 0 TD; 1 rec, -6 yds | 117.8 | RB38 |
| 39 | Breece Hall RB NYJ | 8.3 | 16 car, 54 yds, 0 TD; 2 rec, 9 yds | 190.8 | RB19 |
| 40 | Emanuel Wilson RB GB | 8.2 | 14 car, 82 yds, 0 TD | 83.3 | RB51 |