| # | Player | PPR Pts | Stat Line | Season Pts | Season Rank |
|---|---|---|---|---|---|
| 1 | Derrick Henry RB BAL | 45.6 | 36 car, 216 yds, 4 TD | 272.9 | RB7 |
| 2 | Bijan Robinson RB ATL | 39.9 | 22 car, 195 yds, 1 TD; 5 rec, 34 yds, 1 rec TD | 367.5 | RB2 |
| 3 | Chase Brown RB CIN | 29.1 | 22 car, 101 yds, 2 TD; 3 rec, 40 yds | 259.9 | RB8 |
| 4 | Christian McCaffrey RB SF | 28.1 | 23 car, 140 yds, 1 TD; 4 rec, 41 yds | 402.9 | RB1 |
| 5 | Rhamondre Stevenson RB NE | 27.2 | 8 car, 47 yds, 1 TD; 5 rec, 55 yds, 1 rec TD | 145.5 | RB27 |
| 6 | Zach Charbonnet RB SEA | 26.2 | 18 car, 110 yds, 2 TD; 2 rec, 12 yds | 160.7 | RB25 |
| 7 | Jacory Croskey-Merritt RB WAS | 22.5 | 11 car, 105 yds, 2 TD | 141.4 | RB28 |
| 8 | DS D'Andre Swift RB CHI | 21.0 | 9 car, 54 yds, 2 TD; 2 rec, 16 yds | 225.9 | RB15 |
| 9 | Breece Hall RB NYJ | 20.9 | 14 car, 111 yds, 1 TD; 2 rec, 18 yds | 211.7 | RB17 |
| 10 | Omarion Hampton RB LAC | 20.0 | 14 car, 29 yds, 1 TD; 8 rec, 31 yds | 135.7 | RB33 |
| 11 | RJ Harvey RB DEN | 18.6 | 14 car, 43 yds, 0 TD; 5 rec, 33 yds, 1 rec TD | 204.3 | RB18 |
| 12 | Jonathan Taylor RB IND | 17.4 | 21 car, 70 yds, 1 TD; 3 rec, 14 yds | 356.4 | RB3 |
| 13 | Devin Singletary RB NYG | 17.0 | 8 car, 45 yds, 1 TD; 4 rec, 25 yds | 98.2 | RB46 |
| 14 | Audric Estimé RB NO | 16.8 | 14 car, 94 yds, 1 TD; 1 rec, 4 yds | 32.5 | RB79 |
| 15 | Kyren Williams RB LA | 16.0 | 13 car, 92 yds, 0 TD; 3 rec, 38 yds | 256.2 | RB9 |
| 16 | Aaron Jones RB MIN | 15.3 | 18 car, 53 yds, 1 TD; 3 rec, 10 yds | 120.7 | RB39 |
| 17 | DA De'Von Achane RB MIA | 14.2 | 18 car, 83 yds, 0 TD; 3 rec, 29 yds | 322.1 | RB5 |
| 18 | TP Tony Pollard RB TEN | 11.5 | 18 car, 85 yds, 0 TD; 2 rec, 10 yds | 182.3 | RB22 |
| 19 | Javonte Williams RB DAL | 11.4 | 13 car, 54 yds, 1 TD | 246.8 | RB11 |
| 20 | Travis Etienne RB JAX | 11.2 | 17 car, 76 yds, 0 TD; 2 rec, 16 yds | 249.1 | RB10 |
| 21 | Malik Davis RB DAL | 10.3 | 20 car, 103 yds, 0 TD | 40.6 | RB70 |
| 22 | Brashard Smith RB KC | 9.5 | 0 car, 0 yds, 0 TD; 3 rec, 5 yds, 1 rec TD | 55.5 | RB64 |
| 23 | Kyle Juszczyk RB SF | 9.4 | 0 car, 0 yds, 0 TD; 2 rec, 14 yds, 1 rec TD | 55.5 | RB63 |
| 24 | Rico Dowdle RB CAR | 9.3 | 12 car, 59 yds, 0 TD; 3 rec, 4 yds | 213.3 | RB16 |
| 25 | Ashton Jeanty RB LV | 9.3 | 16 car, 60 yds, 0 TD; 2 rec, 13 yds | 234.7 | RB13 |
| 26 | James Cook RB BUF | 8.7 | 20 car, 74 yds, 0 TD; 1 rec, 3 yds | 306.7 | RB6 |
| 27 | Woody Marks RB HOU | 8.5 | 19 car, 71 yds, 0 TD; 1 rec, 4 yds | 138.3 | RB31 |
| 28 | Jahmyr Gibbs RB DET | 8.4 | 17 car, 41 yds, 0 TD; 2 rec, 23 yds | 348.3 | RB4 |
| 29 | Samaje Perine RB CIN | 8.3 | 3 car, 5 yds, 1 TD; 1 rec, 8 yds | 73.7 | RB57 |
| 30 | Bucky Irving RB TB | 8.3 | 9 car, 19 yds, 0 TD; 5 rec, 14 yds | 129.7 | RB35 |
| 31 | TreVeyon Henderson RB NE | 8.2 | 19 car, 82 yds, 0 TD | 190.9 | RB21 |
| 32 | KW Kenneth Walker III RB SEA | 7.7 | 15 car, 51 yds, 0 TD; 2 rec, 6 yds | 174.6 | RB23 |
| 33 | Kyle Monangai RB CHI | 7.7 | 8 car, 38 yds, 0 TD; 3 rec, 9 yds | 138.8 | RB30 |
| 34 | Saquon Barkley RB PHI | 6.8 | 19 car, 68 yds, 0 TD | 232.3 | RB14 |
| 35 | Kenneth Gainwell RB PIT | 6.8 | 7 car, 26 yds, 0 TD; 3 rec, 12 yds | 201.9 | RB20 |
| 36 | TT Tyrone Tracy Jr. RB NYG | 6.7 | 14 car, 62 yds, 0 TD; 1 rec, -5 yds | 132.9 | RB34 |
| 37 | Jaylen Warren RB PIT | 6.4 | 12 car, 64 yds, 0 TD | 202.2 | RB19 |
| 38 | Michael Carter RB ARI | 6.3 | 7 car, 29 yds, 0 TD; 2 rec, 14 yds | 92.1 | RB48 |
| 39 | David Montgomery RB DET | 6.0 | 10 car, 25 yds, 0 TD; 2 rec, 15 yds | 160.4 | RB26 |
| 40 | Keaton Mitchell RB BAL | 5.8 | 9 car, 31 yds, 0 TD; 2 rec, 7 yds | 55.2 | RB65 |